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Credit: https://www.bloomberg.com/news/articles/2022-04-07/researchers-reverse-ageing-in-human-cells-by-30-years-study?leadSource=uverify%20wall

30 Years Younger? New Study Makes Anti-Aging Breakthrough

April 4, 2022

A new study has turned back the aging clock in human cells by up to 30 years.
In the study, researchers introduced partially rejuvenated human cells to a simulated skin wound.
The findings could help us reverse the effects of age-related diseases such as Alzheimer’s disease and cataracts in the near future.

Scientists have developed a new method that can rewind the aging clock in human cells by up to 30 years without the cells losing their function. According to the Lead researcher of the study, Professor Wolf Reik — who is based at the Altos Labs Cambridge Institute — the findings could have exciting therapeutic applications for anti-aging in the near future. During the study, researchers simulated a skin wound and introduced partially rejuvenated cells that showed signs of behaving like youthful cells. They observed that rejuvenation looked to restore some of the functions of the old cells. The new reprogramming method also had a notable effect on certain genes associated with age-related diseases; such as the MAF gene linked to the development of cataracts, and the APBA2 gene linked to the development of Alzheimer’s disease. “Eventually, we may be able to identify genes that rejuvenate without reprogramming, and specifically target those to reduce the effects of aging. This approach holds promise for valuable discoveries that could open up an amazing therapeutic horizon,” Reik noted. As nature dictates, aging reduces our cells’ ability to function, and accumulates markers of aging in our DNA blueprint. But through regenerative biology, scientists are looking to either replace or repair old cells by introducing ‘induced’ stem cells. The problem is that this process also wipes the cells of their previous functions and erases their identity. The new reprogramming method looks to overcome this issue by stopping the reprogramming process before the cells lose their identity. Ideally, researchers want to find the perfect balance between reprogramming cells to make them younger, and preserving their specialized cell function. According to Dr. Diljeet Gill, a postdoctoral researcher in Professor Reik’s lab, these results “represent a big step forward in our understanding of cell programming.” The study has proved that cells can be rejuvenated without losing their function, and that this rejuvenation can potentially restore some of the function of these old cells. Credit: https://www.bloomberg.com/news/articles/2022-04-07/researchers-reverse-ageing-in-human-cells-by-30-years-study?leadSource=uverify%20wall

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30 Years Younger? New Study Makes Anti-Aging Breakthrough

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