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New study demonstrates the clinical potential of NMN in human beings

May 7, 2021

A new study published in the Science journal found that an antiaging compound known as NMN had beneficial effects on people.
Past studies involving mice have shown that NMN could protect from age-related decline.
Working with prediabetic women, researchers made promising observations but concluded that more needed to be done to establish the full scope of clinical benefits.

A recent study has shown that a compound previously demonstrated to frustrate mechanisms of aging and improve metabolic health in mice also has beneficial effects on human beings. The research was completed by scientists from the Washington University School of Medicine in St. Louis. It was published on April 22 in the Science journal. NMN (nicotinamide mononucleotide) is a compound that naturally occurs in all life forms. It plays an important role in the formation of NAD (Nicotinamide adenine dinucleotide), an enzyme that is involved in countless metabolic processes and whose levels diminish with aging. The decline of NAD has been associated with virtually all diseases of aging, including neurodegeneration, insulin resistance, and even cancer. Previous studies in mice have shown that NMN has numerous benefits, including preventing aging-related health declines such as stiffening of blood vessels and oxidative stress. It also plays an active role in positive gene expression. This was the first study, however, to examine the metabolic effects of NMN in human beings. The researchers studied 25 postmenopausal women with prediabetes. This is a condition where one has higher than normal levels of blood sugar but not high enough to be diagnosed as type 2 diabetes. The study team chose to work entirely on women because past studies in mice had demonstrated greater effects of NMN in female mice. Among the 25 participants, 13 were given a daily dose of 250 mg NMN (administered orally) over 10 weeks. The control group of 12 women was given an inactive placebo daily over the same duration of time. The study demonstrated that NMN administration enhanced the ability of insulin to increase glucose uptake in skeletal muscles, something that is often abnormal in people with prediabetes, obesity, and type 2 diabetes. It also enhanced the expression of genes responsible for muscle structure and remodeling. The research team – however – noted that the treatment did not lower blood glucose or blood pressure, increase insulin sensitivity in the liver, improve blood lipid profile, decrease liver fat, or reduce circulating markers of inflammation as was observed in mice studies. The beneficial effects of NMN in mice have inspired numerous companies around the world to market it as a key ingredient in dietary supplements. But researchers cautioned that more research needs to be done to establish the extent of clinical benefits in human beings. “Although our study shows a beneficial effect of NMN in skeletal muscle, it is premature to make any clinical recommendations based on the results from our study,” said Samuel Klein, a senior study investigator, and professor of medicine and nutritional science at the Washington University School of Medicine. “Normally, when a treatment improves insulin sensitivity in skeletal muscle, as is observed with weight loss or some diabetes medications, there also are related improvements in other markers of metabolic health, which we did not detect in our study participants,” Dr. Klein added.

References: https://www.sciencedaily.com/releases/2021/04/210422150349.htm

New study demonstrates the clinical potential of NMN in human beings

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