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Credit: https://markstengler.com/featured/sarcopenia-the-muscle-wasting-disease/

Is there a cure for sarcopenia?

October 28, 2020

  • A previously known protein complex has been pointed out to slow-down age-related muscle weakness
  • Progression in the excessive loss of function and muscle mass known as Sarcopenia doesn’t have a cure; however, mTORCH1 inhibitors can improve symptoms in the elderly

Sarcopenia is a condition characterized by a progressive decrease in the muscular mass and function of the elderly. This disease affects mostly people over the age of 80, leading primarily to disability and poor life quality. They are multiple causes of this disease. The leading cause has not been determined yet, but factors like age, gender, and coexisting health conditions like diabetes and osteoporosis are considered risk factors.  A protein complex called mTORC1 has been discovered in the past. Still, thanks to a group lead by Prof. Markus Rüedd at the Biozentrum at the University of Basel, a new function has been added to the previous ones known; this new evidence links this protein to the increase the muscle-aging. So far, Rapamycin, a known anti-aging drug, has been one of the few medications able to delay muscle aging in men and mice; this works as a mTORCH1 inhibitor which is known to accelerate the muscle aging,  being able to stabilize the connection between the nervous system and muscles that tends to get worst with age. Prof. Mihaela Zavolan’s team developed the SarcoAtlas tool, a web application supported by the Center of Scientific Computing at the University of Basel to show other researchers how Rapamycin affects skeletal muscle changes. With this study, the researchers are looking to show how the mTORC1 inhibitors can slow-down the muscle weakness linked to Sarcopenia, which affects the elderly.

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