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New compound could be the key to slowing down aging in human bones

February 5, 2021

A new study has revealed a compound capable of slowing down the aging process in bones.
Known as benzoxazole, the compound could potentially slow down aging in humans bones by up to 31%
It is believed to slow down the rate at which osteoclasts—the cells that are active during the healing and growing of bones—are reabsorbed.

A recently concluded longitudinal and functional study carried out at the Buck Institute on 700 aging mice has discovered a compound that could potentially extend animal lifespan— and become a viable anti-aging treatment in the near future. The compound was shown to extend the lifespan of very tiny nematode worms, as well as slow down bone loss in aging mice. The study—which is currently published in the Journal of Bone and Mineral Research Plus—involved the collaboration of five Buck labs, and spanned several years to complete. It involved carefully profiling each of the mice as they age; all while testing different therapeutics that not only reduced the chances of neurological disease in the mice, but also extended lifespan in simple model organisms. During the study, researchers observed notable changes in blood glucose, kyphosis, body composition, and metabolic functions when comparing the treated with the untreated mice. “This is a unique resource that comes from a study of multiple phenotypes of aging that had never been looked at before. Our hope is that our data will enable those working on preclinical studies to essentially model experiments virtually, in order to provide a starting point for testing other interventions in mice,” says Simon Melov, Buck Professor, PhD, and senior author of the paper. The compound in question is known as Benzoxazole, and during the treatment of the mice, it slowed down aging by up to 31%. It was first identified in 2011 as one of five compounds that have the ability to extend nematode lifespan during a Lithgow lab study published in the Nature journal. “It’s obvious that aging-related pathways have been conserved during evolution. This new finding is a great example of the utility of screening compounds in simple animals as the starting point to look for unexpected and surprising benefits in mammals,” said Gordon Lithgow, PhD, Buck professor, and Vice President. According to the published study, benzoxazole was observed to suppress age-related protein aggregation. And while the mechanism by which it acts upon in mouse bone is still under study, researchers believe that it could be slowing down the rate at which osteoclasts are reabsorbed. Osteoclasts are certain bone cells that are actively involved during the healing and growing of bones. Melov believes that this study is critical to humans because mice have a direct correlation to some of the clinical phenotypes found in humans. For example, about 2.5% of aging mice experience spontaneous fractures in their femurs, similar to the 2% of induced hip fractures experienced by aging individuals from all over the world. As such, the researchers believe that this new study could pave way for studying kyphosis—the curving of the spine—and could usher in a new era of testing interventions.

References: https://www.buckinstitute.org/news/a-compound-that-slows-bone-loss-and-a-resource-for-developing-treatments-to-slow-aging/

New compound could be the key to slowing down aging in human bones

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