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SENS Research Foundation is shaping the race to outpace aging

April 16, 2021

Increased interest and research in the field of gerontology offers hope for a future where aging could be treated like any other disease.
SENS Research Foundation funds university research and innovative anti-aging initiatives throughout the world.
The organization’s own gerontology research is investigating the application of regenerative medicine to age-related diseases.

The field of gerontology is growing rapidly as scientists work to understand aging and explore medicines and technology that could help repair or reverse aging processes. Numerous scientific studies have scrutinized the genetic, clinical, behavioral, and social aspects of age-related downtime. While most studies have used model animals such as mice, human trials are ongoing in different parts of the world. The number of companies focused on aging research is also increasing at an impressive pace. One notable organization that is making strides in the race to outrun aging is the SENS Research Foundation. This is an expert-led organization that funds innovative gerontology research and investigates therapies that can cure and prevent the diseases and disabilities of aging. SENS is short for Strategies for Engineered Negligible Senescence. It is an approach to prevent and reverse age-related deterioration by applying the principles of regenerative medicine to repair damage at the level where it occurs. SENS is edging closer to developing regenerative therapies that remove, repair, replace, or render harmless the cellular and molecular damage that has accumulated with time. Essentially – by rebuilding the structured order of the living machinery within the human tissues – SENS rejuvenation technologies will restore normal functioning at the deepest level. “Our vision is a world in which people do not decline in physical or mental health as they get older. We believe it is possible to create medicines that will restore the molecular and cellular structure and composition of the body of a middle-aged (or older) person to something like it was when they were a young adult,” said Dr. Aubrey de Grey, CEO, and co-founder at SENS Research Foundation. Dr. de Grey – who is also the author of ‘Ending Aging’ – argues that if people who are old can function just as well as young adults, then countries will cease to be worried about ‘population aging’. Much of the work at SENS Research Foundation is done at the organization’s internal laboratory, the SRF Research Center. Already, there is an ongoing project to repair mutant mitochondria through gene therapy. This would enable cells to produce proteins that impaired mitochondria can no longer make. A different project is exploring new ways to eliminate damaged cells that the body wants to kill off but cannot. Undergo Pharmaceuticals, a for-profit spinoff of SENS Research Foundation, also conducts some of its research work in this internal lab. The company is already developing solutions for extracting oxidized cholesterol from arteries to help revert atherosclerosis (artery disease). To do their work, SENS Research Foundation’s teams use a broad range of enabler technologies. These may include technologies that are not specific to aging, such as CRISPR, AlphaFold, and CAR-T. In addition to undertaking aging research, SENS also funds research projects in universities around the world. One example is research focused on stem cell therapy for the brain, which could help treat anything from stroke to Alzheimer’s Disease. Another funded initiative explores the removal of fluorescent waste products that accumulate in cells of the heart and other tissues. There’s also a project exploring the molecular structure of the bonds that make arteries stiffer with age. There’s hope – now more than ever – that work completed by SENS Research Foundation and other research teams could soon materialize in clinical practice. “All the necessary areas of damage repair are moving forward quite encouragingly now. Therefore, the only real need is for more financial resources, to get the research to its conclusion (medicines that work) as soon as possible,” said Dr. de Grey.

References: https://researchoutreach.org/articles/age-old-problem-sens-research-foundation-looking-age-related-disease-new-way/amp/

SENS Research Foundation is shaping the race to outpace aging

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