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Credit: https://www.mirror.co.uk/news/uk-news/faecal-transplants-could-rejuvenate-aging-23087801
Are fecal transplants the secret to reversing age-related cognitive declines?
December 6, 2020
- Changes in the brain-gut axis can modify memory and learning abilities in mice
- Age-related changes in microbiota are linked to the overall aging process
The microbiome has been linked to sleeping habits, appetite, weight, and mood changes through connections between the microbiome and the brain. The latest investigations related to microbiome proposed that fecal transplants could increase memory and learning, therefore could be used in the elderly to improve age-related cognitive decline.
During the investigation, a group of investigators from Florence University, East Anglia University, and Norwich Quadram Institute tested mice and performed fecal transplants from older to younger mice that modified microbiome. Younger mice were later tested in a maze test and results showed that memory and spatial learning was affected. At the same time the hippocampus, which involves memory and learning, and nerve transmission reported some changes.
“Research has shown that the aging process may be linked with age-related changes in our gut microbiota,” says Dr. David Vauzour from UEA’s Norwich Medical School, meaning that microbiota also suffers age-related modifications.
The communication between the gastrointestinal tract and the nervous system is known as the “gut-brain axis,” and recent findings have shown that cognitive function and behavior can be modified according to this communication.
“Our research shows that fecal transplantation from an old donor to a young recipient causes an age-associated shift in the composition of gut microbiota. In short, the young mice began to behave like older mice, in terms of their cognitive function.” Says Dr. Vauzour; this statement only asseverates that gut microbiota can affect cognitive function.
It is still unclear if the cognitive function could be restored in the elderly due to microbiota transplant from a younger donor; but it has been demonstrated that the relation between the nervous central system and microbiota exists, says Professor Claudio Nicoletti from the University of Florence. The gut-brain axis should be the center of study to develop therapies where the main goal is improving age-related cognitive decline and quality of life.
The Norwich Research Park has installed a Fecal Microbiota Transplantation (FMT), having one of their goals to investigate the relationship between age-related cognitive decline and gut microbiota.
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