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Deep Longevity releases findings of its new and accurate aging clock

December 28, 2020

Deep Longevity, a Hong-Kong based longevity startup, has recently published scientific findings on its new aging clock
Known as DeepMAge, this biological clock was tested on more than 6,000 DNA methylation profiles with the aim of predicting human age
The clock works by analyzing the methylation patterns in the body to determine the biological age of a person with a 2.77-year error margin

How do aging clocks work? Simply put, they analyze the body’s biomarkers by assessing all the nutritional, environmental, genetic, and therapeutic impacts during the aging process. The use of aging clocks now means that researchers can study different drugs and therapies to see how they affect a person’s lifespan. Aging clocks such as DeepMAge demonstrate the association that age-related conditions such as obesity, dementia, and cancer have to your biological age. According to findings, DeepMAge predicted that women with ovarian cancer were 1.7 years older, on average, than their healthy counterparts of the same chronological age. Moreover, patients that suffered from multiple sclerosis were predicted to be 2.1 years older than their healthy counterparts. In fact, DeepMage is a neural network regressor and it was first put to test on 4,930 blood DNA methylation profiles across 17 studies. The clock works by assigning a higher predicted age to individuals exhibiting underlying health conditions such as multiple sclerosis, ovarian cancer, and irritable bowel disease. The process of DNA methylation is an epigenetic regulatory mechanism. By epigenetic, we mean that it occurs without the influence of genes. Nevertheless, it has the ability to switch gene expression on and off. As we naturally age, the number of methyl groups attached to our DNA increases, resulting in disorientation of gene instructions. This means that genes scheduled to be switched off are switched on and vice-versa. Therefore, a methylation aging clock such as DeepMAge can determine biological age by calculating the number of methyl groups added to our DNA. “We have created DeepMAge to help researchers, health professionals and consumers track aging processes in the organism. As the global population grows older with each generation, the problem of extending the productive period of human lives is getting increasingly important. Solving it is impossible without a way to quantify aging and digitally test our ideas on how to affect it with medicine,” says CEO of Deep Longevity, Alex Zhavoronkov. DeepMAge could play a vital role in the development of early diagnostic tools that detect fast pace aging, and find therapeutic means of solving it. Having the ability to analyze the aging process from a molecular standpoint also means that drug targeting can be carried out on reference models such as DeepMAge, instead of using live subjects. The architecture of neural networks can easily be adjusted to show the effects of lifestyle changes, changes in environment, diet, exercise, and calorie restriction. The approach is that this research will work towards delaying, or perhaps even preventing these diseases, rather than attempting to cure them. Therefore, methylation clocks such as DeepMAge could prove invaluable in determining the long-term risks of new-age drugs.

References: https://www.longevity.technology/deep-longevity-reveals-highly-accurate-aging-clock/

Deep Longevity releases findings of its new and accurate aging clock

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