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(n.) Using new medical science and biohacking to slow down the aging process, repair existing damage and live a dramatically longer life in peak physical and mental health.

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Exploring the science behind the longevity of life

November 1, 2020

  • Aging can be considered a disease that can be targeted, treated, and perhaps even reversed
  • Mediterranean diet can slow the development of age-related inflammatory processes
  • Friendships at age 80 are a bigger predictor of health compared to cholesterol levels

Bulletproof founder and prolific biohacker Dave Asprey recently declared that he wants to live more than 180 years.  In 2014, Ezekiel Emanuel, who is a reputed oncologist and chairman of the Department of Medical Ethics and Health Policy at the University of Pennsylvania, wrote an essay “Why I Hope to Die at 75.” In the essay, Emanuel argued that extended life jeopardizes our creativity and ability to contribute to the world. And, nobody wants to live life unconsciously. Now, the question is, “What if we could change not only our death date but the time leading up to it?” Is this possible? Studies say most people fell ill for about 5-8 years before they die. But, some scientists say that’s not mandatory. They say aging is a disease that can be treated and perhaps even reversed.  Longevity is the latest buzzword in the wellness world, appearing everywhere from gyms to nutrition supplement manufacturers. Meanwhile, big-name investors, including Peter Thiel and Jeff Bezos, are backing pharmaceutical companies to stave off the impairments surrounding the concept of growing old. Nir Barzilai, founding director of the Institute for Aging Research at the Albert Einstein College of Medicine in New York, says exercise is a magic bullet for a healthy, long, and vibrant life. In addition, intermittent fasting stressors can activate the genes in our body that further repair broken DNA while protecting chromosomes.  Barzilai says that along with exercise and fasting, he takes metformin daily, which is an inexpensive diabetes medication. The medicine is believed to limit the amount of sugar the body absorbs with mild side effects.   According to a 2017 study, metformin users are less likely to suffer from illnesses like cancer, dementia, and cardiovascular disease. Though many physicians are prescribing the medicine off-label, Barzilai wants it to be FDA-approved for older adults.  Barzilai says the Mediterranean diet is the best diet in the world. It is high in whole grains, vegetables, fruits, nuts, seeds, olive oil, beans, and low on red meat. According to a study published in the medical journal Gut, following the Mediterranean diet can help slow down age-related inflammatory processes. According to David Sinclair, author of the bestseller Lifespan: Why We Age—and Why We Don’t Have To, the Mediterranean diet tricks our body into thinking that we have been exercising and fasting. But, don’t forget too much of anything, even good things, can be harmful.  Dan Buettner, who popularized the concept of “blue zones,” says longest lived denizens stop eating when their stomach is 80 percent full. Buettner says sugar intake speeds up age-related inflammation.  In addition, stress management, adequate sleep, and social relationships significantly increase life span in older adults.  Neuroscientist Daniel Levitin says that friendships at age 80 are a bigger predictor of health compared to cholesterol levels. Friends and neighbors protect your brain, while loneliness can be the reason behind many medical issues that you can think of. 

What about uncontrollable factors? 

Many of us might inherit diseases that go unnoticed until we see the symptoms. Fortunately, many medical facilities now offer comprehensive DNA sequencing and interpretation of nearly 6,000 disease-associated genes that impair fat breakdown in cells and affect our hearts. Barzilai says in the future, and we can be healthy in our 90s and beyond.

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