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Credit: https://www.technologynetworks.com/tn/news/new-nanotechnology-directs-stem-cells-to-form-bone-tissue-360189

Nanotechnology Offers New Treatment for Osteopathic Disorders

March 31, 2022

  • Scientists have created a nanotechnological structure, a covalent organic framework, to help direct stem cells to bone cells in patients experiencing bone disease. 
  • Researchers have successfully demonstrated that the covalent organic framework can improve bone growth in laboratory models. 
  • Future research on stem-cell-driven nanotechnology could allow rapid repair of bones in patients with osteopathic diseases. 
Pluripotent stem cells can transform into almost any type of cell in the body. Humans rely on stem cells to heal and regenerate following an injury, but the body’s natural use of stem cells is limited. Recent research by Akhilesh K. Gaharwar, Ph.D. at Texas A&M University aims to use nanotechnology to improve the utility of stem cells for healing and repair.  Dr. Gaharwar and his team developed a 2D covalent organic framework (COF) to direct stem cells to travel toward bone cells. A covalent organic framework contains nanoparticles that can interact with stem cells to direct them toward targets within the body. In the case of Dr. Gaharwar’s work, the team developed a COF that successfully guided human mesenchymal stem cells toward bone cells, aiding in bone regeneration.  The nanoparticle’s shape and size determine the COF’s utility, and further research is required to assess the bioactivity of the COF for other applications. A postdoc associate on Dr. Gaharwar’s team, Sukanya Bhunia, commented on the study’s positive results: “the sustained delivery of the drug resulted in enhanced stem cell differentiation towards bone lineage, and this technique can be used for bone regeneration.” The team further improved the efficiency of their COF by adding dexamethasone, an osteo-inducing drug used to stimulate bone growth. Based on the new COF technology, patients with bone disease might one day be able to have their bones rapidly healed through the use of highly directed stem cells. While Dr. Gaharwar hailed their study as an important proof-of-concept, he indicated that significant follow-up research is required to prepare the tech for the treatment of osteopathic diseases.  Credit: https://www.technologynetworks.com/tn/news/new-nanotechnology-directs-stem-cells-to-form-bone-tissue-360189 

References: https://www.technologynetworks.com/tn/news/new-nanotechnology-directs-stem-cells-to-form-bone-tissue-360189

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