Psychedelics startup introduces new magic mushroom nasal spray

Silo Wellness, an Oregon-based psychedelics startup has introduced a metered dosing spray for magic mushrooms, aka psychedelic mushrooms. Magic mushrooms are fungi that grow naturally and produce a hallucinogenic effect. They are classified as psychedelics, drugs which alter perception, thoughts, and mood. The main ingredient in magic mushrooms is psilocybin. Silo Wellness claims that their microdosing nasal spray, which is intended for consumer use, will solve many of the concerns associated with magic mushroom use, such as accessibility, dose reliability, and side effects. “We need to be able to give patients predictable dosing so they can self-titrate to the desired levels of sub-psychedelic or psychedelic treatment,” says Mike Arnold, CEO of Silo Wellness. The magic mushroom nasal spray deals with the perennial problem with plant-based medicine: How to control the dose? And how to ensure you don’t take too much? The metered dosing spray will also address some of the most frequent complaints from mushroom users: upset stomach and taste. The company’s website says the new product is a full-spectrum nasal spray that potentially preserves the entourage effect of psilocybin. The entourage effect is the mechanism by which psychedelic compounds act synergistically to produce psychoactive effects. Even with increasing decriminalization of psilocybin across America, psychedelic mushrooms remain illegal in most states. Silo Wellness developed their product in Jamaica and have tested it on themselves and others. “This isn’t a plan to develop a product or open a facility,” says Michael Hartman, the company’s pharmaceutical product developer. “We have real proof of concept and the research and development are underway.” Some of the company’s competitors offer similar products on the market but incorrectly refer to synthetic or purified psilocybin as magic mushrooms. The truth is there are several potentially active ingredients in the fungi. Silo Wellness has not revealed the precise composition of their microdosing nasal spray but says it is a formulated product that offers a controlled and consistent dose that cannot be achieved with natural mushrooms and other consumer products. The developers state their product is intended for microdosing or sub-perceptual dosing. However, the composition of the nasal spray, the dose size, and the ratios between different compounds have not been revealed. In the pipeline are other psychedelic products, such as ayahuasca and peyote. Silo Wellness has filed a provisional patent for metered dosing formulations of fungal and plant compounds for topical, oral, sublingual, and nasal use. Like many startups in the psychedelic industry, the Silo Wellness team is relying on their experience with cannabis which is similar and synergistic with psychedelics. Hartman is the inventor of Mystabis, a cannabis inhaler, and Arnold has previously represented players in the cannabis industry as an attorney. I never thought I would exit cannabis and pivot full time into psychedelics, but they changed my life. I want to share this medicine with the world by making it affordable and comfortable for all.” – Silo Wellness CEO, Mike Arnold. In the past few years, mainstream media has been covering psychedelics with more enthusiasm. Some are even calling it the psychedelic renaissance. A precipitous increase in scientific research on the benefits of psychedelics and the Denver ballot initiative are the two key factors credited with driving the growth and interest in magic mushrooms. “National media didn’t care about psychedelics until Denver passed their decriminalization ballot measure. Before that, everyone thought I was crazy when I told them we were entering the medicinal psychedelics space in advance of Oregon legalizing in 2020,” says Arnold.