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(n.) Using new medical science and biohacking to slow down the aging process, repair existing damage and live a dramatically longer life in peak physical and mental health.

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SuperAgers have the secret to longevity

November 16, 2020

Through the Longevity Genes Projects, they found that centenarians’ genes have the secret to prevent age-related diseases
During recent studies, the COVID-19 survival rate has been improved in patients taking metformin, a medication used to treat type 2 diabetes
A trial has been developed to study other effects of metformin in age-related cardiovascular and neurological diseases

SuperAgers are known for being older people; however, their cognitive functions, age-related diseases and other conditions related to the elderly are not shown. By not showing these age-related conditions, they can be more active in their daily lives. Numerous researches are focusing on studying the genes of super-agers to establish the mechanism responsible for this unique condition and use this knowledge to develop medications and treatments for age-related diseases. Dr. Nir Barzilai oversees the Longevity Genes Project at Einstein; in these studies, they are working towards developing drugs for cardiovascular conditions, Alzheimer’s, and type 2 diabetes. During these studies, they discovered genes in charge of lipid metabolism then later lead to developing drugs to treat cardiovascular diseases.

Centenarians and COVID-19

COVID-19 has been affecting adults, causing inflammation and lower immune response; however, during studies, they have found that the elderly don’t seem to be affected by these two conditions; an immune response is better in this age group compared to young adults. In general, the health conditions of the centenarians are better than adults at a young age. Dr. Barzilai, director of Einstein-Institute for aging research, has been leading research about age-related diseases, specifically studying centenarians’ genes to develop drugs that prevent aging. He also pointed out that a drug like metformin, which is used to treat an age-related disease like type 2 diabetes was found to improve survival rate in patients with COVID-19 compared with adults who didn’t take this medication. He developed the TAME (Targeting Aging With Metformin) Trial where this FDA-approved medicine will be used and later tested to their effect on age-related diseases like cancer, cardiovascular, and neurological conditions. This trial will have a place on institutions around the country and involves around 3000 individuals with ages between 65-79. “I’m passionate about the therapeutics that are within our reach and their promise to extend health as we grow older. My book may be called “Age Later,” but it really could be called “Healthier Longer.” The promise that we all can live healthier for longer as we grow older and decrease the pain of disease and illness is really what motivates me and my inspiring colleagues in the field,” said Barzilai who keeps working as one of the leaders in multiple investigations related to aging.

References: https://www.afar.org/ask-the-expert/nir-barziliai-md-on-what-we-can-learn-about-longevity-from-superagers-and-centenarians

SuperAgers have the secret to longevity

Centenarians and COVID-19

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